Digidesign Hardware Drivers for Mac OS X, for use with Pro Tools software or as standalone drivers: Digidesign CoreAudio Driver for Tiger (10.4) Digidesign CoreAudio Driver for Panther (10.3) Digidesign CoreAudio Driver for Jaguar (10.2) Avid Free DV for Mac OS X. Digidesign Drivers for Third-Party Applications.
Step two was to change the Hardware Buffer Size to 64 samples. There are no Windows 10 specific drivers but just re-install the latest driver available for the unit. The first part of the solution was to delete and re-install the Mbox 2 Pro drivers.